Respond to two colleagues in one of the following ways:
If your colleagues’ posts influenced your understanding of these concepts, be sure to share how and why. Include additional insights you gained.
If you think your colleagues might have misunderstood these concepts, offer your alternative perspective and be sure to provide an explanation for them. Include resources to support your perspective.
Main Post
Agonist-to-Antagonist Spectrum
The agonist-to-antagonist spectrum of action refers to the action that is taken by a neurotransmitter to produces a conformational change (Stahl, 2013). The spectrum starts with the agonist action, which, with the help of a second-messenger, can turn on the full potential of change (Stahl, 2013). Full agonists can be natural transmitters used to produce change. An antagonist blocks the conformational change of the potential of the transmitter for binding with the intended agonist (Stahl, 2013). The role of the antagonist is to keep the receptors in a baseline state in order to reverse what the agonist has done (Stahl, 2013). This is the opposite end of the spectrum and seeks to block agonists. In the middle, some partial agonists mimic its agonist partner to a lesser degree, and inverse agonists stop all activity from occurring on the receptor (Stahl, 2013). The conformational change is needed for a receptor to open to the action of drugs, particularly, psychopharmaceutical medications in this case.
G couple proteins and Ion gated channels
G couple proteins are used at the binding site of a neurotransmitter to act as a conduit for enzymes (Stahl, 2013). Whereas, ion gated channels exist as targets to regulate chemical neurotransmitters (Stahl, 2013). Ion gated channels consist of channels and receptors that can only be opened by the neurotransmitters. Conversely, G couple proteins attach to neurotransmitters and conform to enzymes to serve as a channel for a second messenger (Stahl, 2013). Most psychotropic medications aim for the ion gated channels, which open through chemical neurotransmission and initiate the signal transduction cascade (Stahl, 2013). The cascade results in faster uptake of psychotropic medications into the system.
The Role of Epigenetics
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alternative perspective was first posted on March 24, 2020 at 9:34 am.
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